Israeli airstrikes have pounded locations across the Gaza Strip, including parts of the south that Israel had declared safe zones.
It has heightened fears among more than two million Palestinians trapped in the territory that nowhere was safe.
In the nearly two weeks since Israel began attacking in response to a devastating Hamas rampage in towns across southern Israel, airstrikes have relentlessly hit the densely populated territory.
Even after Israel told Palestinians to evacuate the north and head to what it called “safe zones” in the south, strikes continued across the entire territory.
The bombardments came after Israel agreed on Wednesday to allow Egypt to deliver limited humanitarian aid to Gaza, the first crack in a punishing 11-day siege.
Many among Gaza’s 2.3 million residents have cut down to one meal a day and have been left to drink dirty water amid dwindling supplies.
The announcement of a plan to bring water, food and other supplies into Gaza happened as fury over the blast at Gaza City’s al Ahli hospital spread across the Middle East, and as US President Joe Biden visited Israel in hopes of preventing a wider conflict in the region.
There were conflicting claims of who was behind the deadly hospital explosion.
Hamas officials in Gaza blamed an Israeli airstrike, saying hundreds were killed.
Israel denied it was involved and released a flurry of video, audio and other information that it said showed the blast was instead due to a rocket misfire by Islamic Jihad, another militant group operating in Gaza.
Islamic Jihad dismissed that claim.
The Associated Press has not independently verified any of the claims or evidence.
Video from the scene showed the hospital grounds strewn with torn bodies, many of them young children.
Hundreds of wounded were rushed to Gaza City’s main hospital where doctors, already facing critical supply shortages, were sometimes forced to perform surgery on the floors, often without anaesthesia.
More than one million Palestinians have fled their homes, roughly half of Gaza’s population.
Many who fled the north and Gaza City, after Israel told them evacuate, have crowded into UN schools or the homes of relatives.
Palestinians in the southern city of Khan Younis said bombings were relentless overnight, with airstrikes hitting several homes, according to the Hamas-led Interior Ministry.
In Rafah, on Egypt’s border, Israel hit several homes.
Medical staff at Nasser Hospital in Khan Younis said they received at least 12 dead and 40 wounded.
Homes along the Gaza border with Israel in the northern evacuation zone were also hit, the ministry said.
Israel has massed troops in the area and is expected to launch a ground invasion into Gaza, though military officials say no decision has been made.
Airstrikes also hit three residential towers in al-Zahra, within the area that was told to evacuate, the Interior Ministry in Gaza said.
Israel has said it is attacking Hamas militants wherever they may be in Gaza and accused the group’s leaders and fighters of taking shelter among the civilian population.
The Israeli military said it killed a top Palestinian militant in Rafah, near the Egyptian border, and hit hundreds of targets across Gaza, including tunnel shafts, intelligence infrastructure and command centres.
It said it hit dozens of mortar launching posts, most of them immediately after they launched shells at Israel.
Palestinians have been launching barrages of rockets at Israel since the fighting began.
The Gaza Health Ministry said 3,478 people have been killed in Gaza since the war began, and more than 12,000 wounded, mostly women, children and the elderly.
Another 1,300 people are believed buried under the rubble, health authorities said.
More than 1,400 people in Israel have been killed, mostly civilians slain during Hamas’s deadly incursion on October 7.
Roughly 200 others were abducted.
The Israeli military said on Thursday it had notified the families of 203 captives.
The strikes across Gaza have left Palestinians feeling they are in constant danger.
The Musa family fled to the typically sleepy central town of Deir al-Balah and took shelter in a cousin’s three-storey home near the local hospital.
But at 7.30pm on Wednesday, a series of explosions, believed to be airstrikes, rocked the building, turning the family home into a mountain of rubble that they said buried some 20 women and children.
The dead body of Hiam Musa, the sister-in-law of Associated Press photojournalist Adel Hana, was recovered from the wreckage on Wednesday evening, the family said.
They do not know who else is under the rubble.
“It doesn’t make sense,” Mr Hana said.
“We went to Deir al-Balah because it’s quiet. We thought we would be safe.”
The Israeli military said it was investigating.
Violence between Israel and Hezbollah militants in Lebanon has also flared in recent days amid fears the fighting could spread across the region.
In the West Bank, where scores of Palestinians have been killed since the war started, Israeli forces have killed dozens of Palestinians in the past two days, according to the Palestinian Health Ministry.
The deal to get aid into Gaza remained fragile.
Mr Biden said Egypt’s president agreed to open the Rafah crossing to let in an initial group of 20 lorries with humanitarian aid.
If Hamas confiscates aid, “it will end”, he said.
The aid will start moving on Friday at the earliest, White House officials said.
Egypt must still repair the road across the border, which was cratered by Israeli airstrikes.
More than 200 lorries and some 3,000 tons (about 2,721.6 tonnes) of aid are positioned at or near the crossing, Gaza’s only connection to Egypt, said the head of the Red Crescent for North Sinai, Khalid Zayed.
Supplies will go in under supervision of the UN, Egyptian foreign minister Sameh Shoukry told Al-Arabiya TV.
Asked if foreigners and dual nationals seeking to leave would be let through, he said: “As long as the crossing is operating normally and the (crossing) facility has been repaired.”
Israeli Prime Minister Benjamin Netanyahu’s office said the decision was approved after a request from Mr Biden.
It said Israel “will not thwart” deliveries of food, water or medicine from Egypt, as long as they are limited to civilians in the south of the Gaza Strip and do not go to Hamas militants.
The statement made no mention of fuel, which is badly needed for hospital generators.
Relatives of some of the roughly 200 people taken hostage and forced back to Gaza during the attack reacted in fury to the aid announcement.
“Children, infants, women, soldiers, men, and elderly, some with serious illnesses, wounded and shot, are held underground like animals,” said a statement from the Hostage and Missing Families Forum.
But “the Israeli government pampers the murderers and kidnappers”.
In his brief visit, Mr Biden tried to strike a balance between showing US support for Israel and containing growing alarm among Arab allies.
He also announced 100 million US dollars (£82.5 million) in humanitarian aid for Palestinians in Gaza and the West Bank.
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