A breakthrough material developed by scientists in Glasgow will make it easier to transport and store medicines including cancer treatments without the need for fridges or freezers.

Researchers from the universities of Manchester, Glasgow and Warwick, have created a hydrogel – a material mostly made of water – that stabilises proteins at temperatures as high as 50°C.

Protein therapeutics are used to treat a range of conditions, from cancer to diabetes and most recently to treat obesity, and play a vital role in modern medicine and biotechnology.

However, it is much more difficult to keep protein-based drugs from deteriorating in developing countries which lack cold storage infrastructure. 

This was a major obstacle in the early days of the Covid vaccination rollout, because the mRNA vaccines developed by Moderna and Pfizer had to be kept frozen during transit.

The researchers - whose work is published in the journal, Nature - hope that the hydrogel can significantly improve access to these medicines in hot and poorer countries. 

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Dave Adams, a professor at Glasgow University's School of Chemistry, is one of the paper’s corresponding authors.

He said: “In the early days of the Covid vaccine rollout, there was a lot of attention given in the news media to the challenges of transporting and storing the vaccines, and how medical staff had to race to put them in people’s arms quickly after thawing.

“The technology we’ve developed marks a significant advance in overcoming the challenges of the existing ‘cold chain’ which delivers therapeutic proteins to patients.

"The results of our tests have very encouraging results, going far beyond current hydrogel storage techniques’ abilities to withstand heat and vibration.

"That could help create much more robust delivery systems in the future, which require much less careful handling and temperature management.”

Pfizer and Moderna Covid vaccines had to be kept extremely coldPfizer and Moderna Covid vaccines had to be kept extremely cold (Image: Getty)

The hydrogel keeps proteins so stable that they can even be sent through the post with no loss of effectiveness, opening up new possibilities for more affordable, less energy-intensive methods of keeping patients and clinics supplied with vital treatments.

The hydrogel is built from a material called a low molecular weight gelator (LMWG), which forms a three-dimensional network of long, stiff fibres.

When proteins are added to the hydrogel, they become trapped in the spaces between the fibres.

When the protein-storing gel is stored in an ordinary syringe fitted with a special filter, pushing down on the plunger provides enough pressure to break the network of fibres, releasing the protein.

The protein then passes cleanly through the filter and out the tip of the syringe, leaving the gel behind.

In the paper, the researchers show how the hydrogel works to store two valuable proteins: insulin, used to treat diabetes, and beta-galactosidase, an enzyme with numerous applications in biotechnology and life sciences.

Ordinarily, insulin must be kept cold and still, as heating or shaking can prevent it from being an effective treatment.

The technology will be especially useful in developing countries with very hot weather and lack of infrastructure for cold storageThe technology will be especially useful in developing countries with very hot weather and lack of infrastructure for cold storage (Image: Getty)

The team tested the effectiveness of their hydrogel suspension for insulin by warming samples to 25°C and rotating them at 600 revolutions per minute, a strain test far beyond any real-world scenario.

Once the tests were complete, the team were able to recover the entire volume of insulin from the hydrogel, showing that it had been protected from its rough treatment.

The team then tested samples of beta-galactosidase in the hydrogel, which was stored at a temperature of 50°C for seven days, a level of heat exceeding any realistic temperature for real-world transport.

Once the enzyme was extracted from the hydrogel, the team found it retained 97% of its function compared against a fresh sample stored at normal temperature.

A third test saw the team put samples of proteins suspended in hydrogel into the post, where they spent two days in transit between locations.

Once the sample arrived at its destination, the team’s analysis showed that the gels’ structures remained intact and the proteins wee unaffected.

Co-author, Professor Matthew Gibson, from Manchester University, added: “Delivering and storing proteins intact is crucial for many areas of biotechnology, diagnostics and therapies.

"Recently, it has emerged that hydrogels can be used to prevent protein aggregation, which allows them to be kept at room temperature, or warmer.

"However, separating the hydrogel components from the protein or proving that they are safe to consume is not always easy.

"Our breakthrough eliminates this barrier and allows us to store and distribute proteins at room temperature, free from any additives, which is a really exciting prospect.”