Hurricane Ida has become a dangerous Category 4 hurricane on track for a potentially devastating landfall on the Louisiana coast.
The US National Hurricane Centre said the system has maximum sustained winds of 140mph and is expected to make landfall on Sunday afternoon.
The storm arrived on the exact date Hurricane Katrina ravaged Louisiana and Mississippi 16 years earlier.
Ida rapidly intensified as it moved into the northern Gulf, going from top winds of 115mph in a 1am update to 140mph just a few hours later.
The storm was centred about 75 miles south of the mouth of the Mississippi River and 145 miles south-east of coastal Houma, Louisiana, and was travelling north-west at 15mph.
The storm threatened a region already reeling from a resurgence of Covid-19 infections, thanks to low vaccination rates and the highly contagious Delta variant.
New Orleans hospitals planned to ride out the storm with their beds nearly full, as similarly stressed hospitals elsewhere had little room for evacuated patients.
And shelters for those fleeing their homes carried an added risk of becoming flashpoints for new infections.
Governor John Bel Edwards vowed that Louisiana's "resilient and tough people" would weather the storm.
He also noted shelters would operate with reduced capacities "to reflect the realities of Covid".
Mr Edwards said Louisiana officials were already working to find hotel rooms for many evacuees so that fewer had to stay in mass shelters.
He noted that during last year's hurricane season, Louisiana found rooms for 20,000 people.
"So, we know how to do this," Mr Edwards said. "I hope and pray we don't have to do it anywhere near that extent."
President Joe Biden approved emergency declarations for Louisiana and Mississippi ahead of Ida's arrival.
Comparisons to the August 29 2005 landfall of Katrina weighed heavily on residents bracing for Ida.
A Category 3 storm, Katrina was blamed for 1,800 deaths as it demolished oceanfront homes in Mississippi and caused levee breaches and catastrophic flooding in New Orleans.
In Saucier, Mississippi, Alex and Angela Bennett spent Saturday afternoon filling sand bags to place around their flood-prone home.
Both survived Katrina, and did not expect Ida to cause nearly as much destruction where they live, based on forecasts.
"Katrina was terrible. This ain't gonna be nothing," Alex Bennett said.
"I hate it for Louisiana, but I'm happy for us."
Long lines formed at petrol stations on Saturday as people rushed to escape.
Trucks pulling saltwater fishing boats and campers streamed away from the coast on Interstate 65 in Alabama, while traffic jams clogged Interstate 10 heading out of New Orleans.
Ida intensified so swiftly that New Orleans officials said there was no time to organise a mandatory evacuation of its 390,000 residents.
Mayor LaToya Cantrell urged residents to leave voluntarily.
Those who stayed were warned to prepare for long power outages amid sweltering heat.
Officials also stressed that the levee and drainage systems protecting the city had been much improved since Katrina.
But they cautioned flooding was still possible, with up to 24in of rain forecast in some areas.
Ida posed a threat far beyond New Orleans.
A hurricane warning was issued for nearly 200 miles of Louisiana's coastline, from Intracoastal City south of Lafayette to the Mississippi state line.
A tropical storm warning was extended to the Alabama-Florida line.
Meteorologist Jeff Masters, who flew hurricane missions for the government and founded Weather Underground, said Ida is forecast to move through "the just absolute worst place for a hurricane".
The Interstate 10 corridor between New Orleans and Baton Rouge is a critical hub of the nation's petrochemical industry, lined with oil refineries, natural gas terminals and chemical manufacturing plants.
Entergy, Louisiana's major electricity provider, operates two nuclear power plants along the Mississippi River.
A US Energy Department map of oil and gas infrastructure shows scores of low-lying sites in the storm's projected path that are listed as potentially vulnerable to flooding.
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