The pound tumbled to eight-week lows on Tuesday as investors started to fret over the prospect of a second Scottish referendum and the pending trigger of Article 50.
Sterling fell more than 0.6% against the US dollar to trade at 1.214, marking its lowest level since mid-January.
The currency was also hovering near eight-week lows versus the euro, dropping 0.5% to trade at 1.140.
The pound was suffering in part from delayed investor reaction to yesterday's news, when Scotland's First Minister outlined plans to launch a second independence referendum, and Downing Street signalled the Prime Minister would trigger Article 50 at the end of March.
Connor Campbell, a financial analyst at SpreadEx, said: "It appears that there are a few things in play here. The pound could be belatedly reacting to Nicola Sturgeon's announcement of a second Scottish independence referendum, something that it basically ignored on Monday.
"Then there is the news that Article 50 will be triggered at the end of March - hardly an unforeseen problem, but one that carries a sting in its tail nonetheless."
Theresa May was widely expected to trigger the start of Brexit negotiations this week, but plans to do so at the end of the month will allow the Dutch elections and the EU's sixtieth anniversary to take place without being overshadowed by Article 50.
The pound exchange rate was also impacted by a stronger US dollar, which was on the rise in anticipation of an interest rate hike by the Federal Reserve on Wednesday.
It would mark the third interest rate rise by the US central bank since the financial crisis.
The FTSE 100 made minimal gains, rising 0.1% to around 7,373 points, while its European counterparts were trading lower.
The French Cac 40 fell 0.3% while the German Dax dropped nearly 0.1%.
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